Sanford (Sandy) Dawsey, MD

Dr. Dawsey recentlyretired as a Senior Investigator at the National Cancer Institute of theNational Institutes of Health, where he worked for 36 years. During his time atNIH, his main focus was the prevention and control of esophageal squamous cellcarcinoma (ESCC).  He performed multiplestudies in China, Iran, Brazil and East Africa to understand the etiology ofthis cancer globally in high-risk populations, and he helped develop clinicallyuseful early detection and treatment techniques for this disease. With US andChinese colleagues, he developed an endoscopic early detection and treatmentprogram for esophageal squamous cell carcinoma that is now used in a nationalprogram to screen over 200,000 adults annually in high-risk areas of China, andthis program has been shown to reduce ESCC mortality by ~33% over 10 years.Most recently, he was a founding member of the African Esophageal CancerConsortium (AfrECC), which was created to perform coordinated etiologic, earlydetection and treatment, and palliation studies to try to reduce the burden ofESCC in Africa. He is currently President of the Board of the AfricanEsophageal Cancer Consortium Foundation.

ETIOLOGY WORKING GROUP

Leadership:

Hannah Simba, APHRC
Yukiko Yano, US National Cancer Institute
CLINICAL WORKING GROUP

Leadership:

Yona Ringo, Tanzania
Lucien Ferndale, South Africa

AfrECC Research

Etiology

Working Group

AfrECC Working Groups are subgroups within the AfrECC consortium that are focused on specific related activities. At the time of application for AfrECC membership, each potential new member will be asked which working group(s) they would like to be a member of. The AfrECC Etiology Working Group includes AfrECC members who are conducting etiologic and molecular studies of esophageal cancer in Africa. These include studies of the genetic, environmental and lifestyle risk factors and mechanistic pathways for esophageal cancer and its precursors.

Major Activities

  • Completion of 7 case-control studies across multiple African sites, enrolling approximately 2,400 cases and 2,400 controls, using harmonized mHealth-based data collection tools.
  • In-depth exposure assessments, including hot beverage consumption, household polycyclic aromatic hydrocarbon (PAH) exposure, and micronutrient deficiencies.
  • Expansion of molecular and genomic research, including a coordinated consortium-wide genome-wide association study (GWAS).
  • AfrECC Etiology Pooling Project: A continent-wide effort to combine individual-level data from high-quality African studies, coordinated by the International Agency for Research on Cancer, to increase statistical power and enable robust cross-regional analyses.

AfrECC Research

Clinical

Working Group

The AfrECC Clinical Working Group includes members whose work aims to improve early detection and clinical care of patients with esophageal cancer.

Major Activities

  • An endoscopic capacity survey in 4 countries documented severe shortages in both endoscopic equipment and trained endoscopists compared to western countries.
  • An endoscopic screening study in Kenya showed that 14% of asymptomatic adults had esophageal squamous dysplasia, the curable precursor of ESCC
  • The AfrECC Stent Access Initiative, sponsored by Boston Scientific Corporation and Olympus Corporation,provides access to discounted self-expanding metal stents (SEMS) and conducts workshops to train local endoscopists to insert these stents for palliation of advanced stage ESCC. Since 2018, this hands-on training initiative has conducted 19 workshops in 8 countries, training 66 doctor-nurse endoscopy teams and stenting 344 patients.

AfrECC

Publications

2023

A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa.

Genomic Profiling and Methylation Studies
View Publication

2023

Survival after Diagnosis of Esophageal Squamous Cell Carcinoma in Malawi.

Treatment, Survival and Survivorship
View Publication

2022

Expanding Oesophageal Cancer Research and Care in Eastern Africa.

Calls to Action, Overviews and Commentaries
View Publication

2022

An International Report on Bacterial Communities in Esophageal Squamous Cell Carcinoma.

Aetiology
View Publication

2022

Alcohol Consumption and Oesophageal Squamous Cell Cancer Risk in East Africa: Findings from the Large Multicentre Esccape Case-Control Study in Kenya, Tanzania, and Malawi.

Aetiology
View Publication

2022

A Very-Hot Food and Beverage Thermal Exposure Index and Esophageal Cancer Risk in Malawi and Tanzania: Findings from the Esccape Case-Control Studies.

Aetiology
View Publication

2022

The Evidence Gap between Alcohol Consumption and Oesophageal Squamous Cell Carcinoma in East Africa - Authors' Reply.

Aetiology
View Publication

2022

Alcohol Consumption as a Risk Factor for Oesophageal Squamous Cell Carcinoma Risk in Sub-Saharan Africa.

Aetiology
View Publication

2022

Tobacco and Other Risk Factors for Esophageal Squamous Cell Carcinoma in Lilongwe Malawi: Results from the Lilongwe Esophageal Cancer Case: Control Study.

Aetiology
View Publication

2022

Risk Factors Associated with Early-Onset Esophageal Cancer in Tanzania.

Aetiology
View Publication

2022

Prevalence of Esophageal Squamous Dysplasia in Relatives of Patients with Esophageal Cancer in Southwestern Kenya.

Early Detection
View Publication

2022

Predictors of Adverse Events and Early Mortality after Esophageal Stent Placement in a Low Resource Setting: A Series of 3823 Patients in Kenya.

Treatment, Survival and Survivorship
View Publication

Upcoming Event Calendar

Cadence: Quarterly | Etiology Working Group Meeting
Led by: Hannah Simba and Yukiko Yano

Cadence: Quarterly | Clinical Working Group Meeting
Led by: Lucien Ferndale and Yona Ringo

AfrECC

Research Library

Browse peer-reviewed publications produced by the AfrECC consortium.