Sanford (Sandy) Dawsey, MD

Dr. Dawsey recentlyretired as a Senior Investigator at the National Cancer Institute of theNational Institutes of Health, where he worked for 36 years. During his time atNIH, his main focus was the prevention and control of esophageal squamous cellcarcinoma (ESCC).  He performed multiplestudies in China, Iran, Brazil and East Africa to understand the etiology ofthis cancer globally in high-risk populations, and he helped develop clinicallyuseful early detection and treatment techniques for this disease. With US andChinese colleagues, he developed an endoscopic early detection and treatmentprogram for esophageal squamous cell carcinoma that is now used in a nationalprogram to screen over 200,000 adults annually in high-risk areas of China, andthis program has been shown to reduce ESCC mortality by ~33% over 10 years.Most recently, he was a founding member of the African Esophageal CancerConsortium (AfrECC), which was created to perform coordinated etiologic, earlydetection and treatment, and palliation studies to try to reduce the burden ofESCC in Africa. He is currently President of the Board of the AfricanEsophageal Cancer Consortium Foundation.

ETIOLOGY WORKING GROUP

Leadership:

Hannah Simba, APHRC
Yukiko Yano, US National Cancer Institute
CLINICAL WORKING GROUP

Leadership:

Yona Ringo, Tanzania
Lucien Ferndale, South Africa

AfrECC Research

Etiology

Working Group

AfrECC Working Groups are subgroups within the AfrECC consortium that are focused on specific related activities. At the time of application for AfrECC membership, each potential new member will be asked which working group(s) they would like to be a member of. The AfrECC Etiology Working Group includes AfrECC members who are conducting etiologic and molecular studies of esophageal cancer in Africa. These include studies of the genetic, environmental and lifestyle risk factors and mechanistic pathways for esophageal cancer and its precursors.

Major Activities

  • Completion of 7 case-control studies across multiple African sites, enrolling approximately 2,400 cases and 2,400 controls, using harmonized mHealth-based data collection tools.
  • In-depth exposure assessments, including hot beverage consumption, household polycyclic aromatic hydrocarbon (PAH) exposure, and micronutrient deficiencies.
  • Expansion of molecular and genomic research, including a coordinated consortium-wide genome-wide association study (GWAS).
  • AfrECC Etiology Pooling Project: A continent-wide effort to combine individual-level data from high-quality African studies, coordinated by the International Agency for Research on Cancer, to increase statistical power and enable robust cross-regional analyses.

AfrECC Research

Clinical

Working Group

The AfrECC Clinical Working Group includes members whose work aims to improve early detection and clinical care of patients with esophageal cancer.

Major Activities

  • An endoscopic capacity survey in 4 countries documented severe shortages in both endoscopic equipment and trained endoscopists compared to western countries.
  • An endoscopic screening study in Kenya showed that 14% of asymptomatic adults had esophageal squamous dysplasia, the curable precursor of ESCC
  • The AfrECC Stent Access Initiative, sponsored by Boston Scientific Corporation and Olympus Corporation,provides access to discounted self-expanding metal stents (SEMS) and conducts workshops to train local endoscopists to insert these stents for palliation of advanced stage ESCC. Since 2018, this hands-on training initiative has conducted 19 workshops in 8 countries, training 66 doctor-nurse endoscopy teams and stenting 344 patients.

AfrECC

Publications

2022

Management of Esophageal Cancer Treatment in Resource-Limited Settings.

Treatment, Survival and Survivorship
View Publication

2022

Treatment Outcomes of Esophageal Cancer in Eastern Africa: Protocol of a Multi-Center, Prospective, Observational, Open Cohort Study.

Treatment, Survival and Survivorship
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2021

Esophageal Cancer in Tanzania: A Welcome Stimulus in Primary Prevention Research.

Calls to Action, Overviews and Commentaries
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2021

A Concise Review Towards Defining the Exposome of Oesophageal Cancer in Sub-Saharan Africa.

Descriptive Epidemiology and Case Series
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2021

Geophagia and Risk of Squamous Cell Esophageal Cancer in the African Esophageal Cancer Corridor: Findings from the Esccape Multicountry Case-Control Studies.

Aetiology
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2021

Indoor Wood Combustion, Carcinogenic Exposure and Esophageal Cancer in Southwest Kenya.

Aetiology
View Publication

2021

A Case-Control Study to Evaluate Environmental and Lifestyle Risk Factors for Esophageal Cancer in Tanzania.

Aetiology
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2021

Missing and Decayed Teeth, Oral Hygiene and Dental Staining in Relation to Esophageal Cancer Risk: Esccape Case-Control Study in Kilimanjaro, Tanzania.

Aetiology
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2021

Mutational Signatures in Esophageal Squamous Cell Carcinoma from Eight Countries with Varying Incidence.

Genomic Profiling and Methylation Studies
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2021

Genome-Wide DNA Methylation Profiling of Esophageal Squamous Cell Carcinoma from Global High-Incidence Regions Identifies Crucial Genes and Potential Cancer Markers.

Genomic Profiling and Methylation Studies
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2021

Larger Esophageal Lugol's Unstained Lesions Need More Follow-Up: Size as an Important Predictor for Risk of Premalignant Lesions.

Early Detection
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2021

The Use of Questionnaire-Based Risk-Stratification Tools in Screening for Esophageal Squamous Cell Carcinoma.

Early Detection
View Publication

Upcoming Event Calendar

Cadence: Quarterly | Etiology Working Group Meeting
Led by: Hannah Simba and Yukiko Yano

Cadence: Quarterly | Clinical Working Group Meeting
Led by: Lucien Ferndale and Yona Ringo

AfrECC

Research Library

Browse peer-reviewed publications produced by the AfrECC consortium.