Sanford (Sandy) Dawsey, MD

Dr. Dawsey recentlyretired as a Senior Investigator at the National Cancer Institute of theNational Institutes of Health, where he worked for 36 years. During his time atNIH, his main focus was the prevention and control of esophageal squamous cellcarcinoma (ESCC).  He performed multiplestudies in China, Iran, Brazil and East Africa to understand the etiology ofthis cancer globally in high-risk populations, and he helped develop clinicallyuseful early detection and treatment techniques for this disease. With US andChinese colleagues, he developed an endoscopic early detection and treatmentprogram for esophageal squamous cell carcinoma that is now used in a nationalprogram to screen over 200,000 adults annually in high-risk areas of China, andthis program has been shown to reduce ESCC mortality by ~33% over 10 years.Most recently, he was a founding member of the African Esophageal CancerConsortium (AfrECC), which was created to perform coordinated etiologic, earlydetection and treatment, and palliation studies to try to reduce the burden ofESCC in Africa. He is currently President of the Board of the AfricanEsophageal Cancer Consortium Foundation.

ETIOLOGY WORKING GROUP

Leadership:

Hannah Simba, APHRC
Yukiko Yano, US National Cancer Institute
CLINICAL WORKING GROUP

Leadership:

Yona Ringo, Tanzania
Lucien Ferndale, South Africa

AfrECC Research

Etiology

Working Group

AfrECC Working Groups are subgroups within the AfrECC consortium that are focused on specific related activities. At the time of application for AfrECC membership, each potential new member will be asked which working group(s) they would like to be a member of. The AfrECC Etiology Working Group includes AfrECC members who are conducting etiologic and molecular studies of esophageal cancer in Africa. These include studies of the genetic, environmental and lifestyle risk factors and mechanistic pathways for esophageal cancer and its precursors.

Major Activities

  • Completion of 7 case-control studies across multiple African sites, enrolling approximately 2,400 cases and 2,400 controls, using harmonized mHealth-based data collection tools.
  • In-depth exposure assessments, including hot beverage consumption, household polycyclic aromatic hydrocarbon (PAH) exposure, and micronutrient deficiencies.
  • Expansion of molecular and genomic research, including a coordinated consortium-wide genome-wide association study (GWAS).
  • AfrECC Etiology Pooling Project: A continent-wide effort to combine individual-level data from high-quality African studies, coordinated by the International Agency for Research on Cancer, to increase statistical power and enable robust cross-regional analyses.

AfrECC Research

Clinical

Working Group

The AfrECC Clinical Working Group includes members whose work aims to improve early detection and clinical care of patients with esophageal cancer.

Major Activities

  • An endoscopic capacity survey in 4 countries documented severe shortages in both endoscopic equipment and trained endoscopists compared to western countries.
  • An endoscopic screening study in Kenya showed that 14% of asymptomatic adults had esophageal squamous dysplasia, the curable precursor of ESCC
  • The AfrECC Stent Access Initiative, sponsored by Boston Scientific Corporation and Olympus Corporation,provides access to discounted self-expanding metal stents (SEMS) and conducts workshops to train local endoscopists to insert these stents for palliation of advanced stage ESCC. Since 2018, this hands-on training initiative has conducted 19 workshops in 8 countries, training 66 doctor-nurse endoscopy teams and stenting 344 patients.

AfrECC

Publications

2019

Esophageal Thermal Exposure to Hot Beverages: A Comparison of Metrics to Discriminate Distinct Consumption Habits.

Aetiology
View Publication

2019

Hot Beverages and Oesophageal Cancer Risk in Western Kenya: Findings from the Esccape Case-Control Study.

Aetiology
View Publication

2019

Dental Fluorosis and Oral Health in the African Esophageal Cancer Corridor: Findings from the Kenya Esccape Case-Control Study and a Pan-African Perspective.

Aetiology
View Publication

2019

Traditional and Commercial Alcohols and Esophageal Cancer Risk in Kenya.

Aetiology
View Publication

2019

Through-the-Scope Esophageal Stents for Malignant Dysphagia: A Double-Edged Sword?

Treatment, Survival and Survivorship
View Publication

2018

The African Esophageal Cancer Consortium: A Call to Action.

Calls to Action, Overviews and Commentaries
View Publication

2018

Characteristics of Esophageal Cancer Cases in Tanzania.

Descriptive Epidemiology and Case Series
View Publication

2018

Esophageal Cancer Male to Female Incidence Ratios in Africa: A Systematic Review and Meta-Analysis of Geographic, Time and Age Trends.

Descriptive Epidemiology and Case Series
View Publication

2018

Cancer Epidemiology Fieldwork in a Resource-Limited Setting: Experience from the Western Kenya Esccape Esophageal Cancer Case-Control Pilot Study.

Aetiology
View Publication

2018

Frequent Hiv and Young Age among Individuals with Diverse Cancers at a National Teaching Hospital in Malawi.

Aetiology
View Publication

2017

International Cancer Seminars: A Focus on Esophageal Squamous Cell Carcinoma.

Calls to Action, Overviews and Commentaries
View Publication

2017

Cross Sectional Study of Serum Selenium Concentration and Esophageal Squamous Dysplasia in Western Kenya.

Aetiology
View Publication

Upcoming Event Calendar

Cadence: Quarterly | Etiology Working Group Meeting
Led by: Hannah Simba and Yukiko Yano

Cadence: Quarterly | Clinical Working Group Meeting
Led by: Lucien Ferndale and Yona Ringo

AfrECC

Research Library

Browse peer-reviewed publications produced by the AfrECC consortium.

AfrECC Foundation Board Members

David Fleischer, MD

Location: 

Washington DC, USA

Title: 

Emeritus Professor of Medicine Mayo Clinic College of Medicine

Foundation Role: 

Chairman, Board of Directors

Sanford (Sandy) Dawsey, MD

Location: 

Washington DC area, USA

Title: 

Retired Senior Investigator from the National Cancer Institute

Foundation Role: 

President, Board of Directors

Violet Kayamba, BScHB, MBChB, MMed, FCP(ECSA), Ph.D

Location: 

Lusaka, Zambia

Title: 

Senior Lecturer, University of Zambia School of Medicine

Foundation Role: 

Vice President, Board of Directors

Jim O'Hara

Location: 

Washington, DC area, USA

Title: 

CFO, PM Hotel Group

Foundation Role: 

Treasurer, Board of Directors

Dorene E. McCourt, MBA

Location: 

Boston, MA, USA

Title: 

Pharmaceutical marketing and sales executive (retired)

Foundation Role: 

Secretary, Board of Directors

Lilly Alfonso

Location: 

Lilongwe, Malawi

Title: 

CEO, Founder & Head Designer, Lilly Alfonso

Foundation Role: 

Board Member

Vivian Kobusingye Birchall, SM

Location: 

Massachusetts, USA

Title: 

Founder & CEO, Health Care Blind Spots Consulting

Foundation Role: 

Board Member

Geoffrey (Geoff) Buckle, MD, MPH

Location: 

San Francisco, California, USA

Title: 

Assistant Professor in the Division of Hematology/Oncology at the University of California, San Francisco (UCSF)

Foundation Role: 

Board member

Chloë Cooney

Location: 

Washington DC, USA

Title: 

Director of U.S. Strategy for Gavi

Foundation Role: 

Board member; Leader of Strategic Planning Task Force

Gift Mulima, MD

Location: 

Lilongwe, Malawi

Title: 

General Surgeon, Kamuzu Central Hospital

Foundation Role: 

Board member

Diana Menya, BSc, MBChB, MSc, PhD

Location: 

Eldoret, Kenya

Title: 

Epidemiologist, Moi University

Foundation Role: 

Board member

Beatrice Paul Mushi, MD, MPH.

Location: 

Dar-es Salaam, Tanzania

Title: 

Program Manager, Cancer Collaboration Program, Muhimbili University of Health and Allied Sciences, Ocean Road Cancer Institute, and University of California San Francisco (MUHAS-ORCI-UCSF)

Foundation Role: 

Board member

Michael Mwachiro, MD

Location: 

Nairobi, Kenya

Title: 

Consultant General Surgeon and Interventional Endoscopist, Avenue HealthCare

Foundation Role: 

Board member

Ike Ogbuebile, MA, MiPD

Location: 

Washington DC area, USA

Title: 

Founder & CEO, Encase Consulting

Foundation Role: 

Board member

John Sims

Location: 

Boston, Massachusetts, USA

Title: 

President and CEO of AJS Consulting Company, LLC.

Foundation Role: 

Board member

Mark Topazian, MD

Location: 

Addis Ababa, Ethiopia

Title: 

Gastroenterologist

Foundation Role: 

Board member

Jerome (Jerry) D. Waye, MD

Location: 

New York area, USA

Title: 

Emeritus Professor of Medicine, Mt Sinai, New York

Foundation Role: 

Board member; Leader of the Remote Endoscopic Teaching Task Force

Chloë Cooney

Location: 

Washington DC, USA

Title: 

Director of U.S. Strategy for Gavi

Foundation Role: 

Board member; Leader of Strategic Planning Task Force

Gift Mulima, MD

Location: 

Lilongwe, Malawi

Title: 

General Surgeon, Kamuzu Central Hospital

Foundation Role: 

Board member

Diana Menya, BSc, MBChB, MSc, PhD

Location: 

Eldoret, Kenya

Title: 

Epidemiologist, Moi University

Foundation Role: 

Board member

Beatrice Paul Mushi, MD, MPH.

Location: 

Dar-es Salaam, Tanzania

Title: 

Program Manager, Cancer Collaboration Program, Muhimbili University of Health and Allied Sciences, Ocean Road Cancer Institute, and University of California San Francisco (MUHAS-ORCI-UCSF)

Foundation Role: 

Board member

Michael Mwachiro, MD

Location: 

Nairobi, Kenya

Title: 

Consultant General Surgeon and Interventional Endoscopist, Avenue HealthCare

Foundation Role: 

Board member

Ike Ogbuebile, MA, MiPD

Location: 

Washington DC area, USA

Title: 

Founder & CEO, Encase Consulting

Foundation Role: 

Board member

John Sims

Location: 

Boston, Massachusetts, USA

Title: 

President and CEO of AJS Consulting Company, LLC.

Foundation Role: 

Board member

Mark Topazian, MD

Location: 

Addis Ababa, Ethiopia

Title: 

Gastroenterologist

Foundation Role: 

Board member

Chloë Cooney

Location: 

Washington DC, USA

Title: 

Director of U.S. Strategy for Gavi

Foundation Role: 

Board member; Leader of Strategic Planning Task Force

Gift Mulima, MD

Location: 

Lilongwe, Malawi

Title: 

General Surgeon, Kamuzu Central Hospital

Foundation Role: 

Board member

Diana Menya, BSc, MBChB, MSc, PhD

Location: 

Eldoret, Kenya

Title: 

Epidemiologist, Moi University

Foundation Role: 

Board member

Beatrice Paul Mushi, MD, MPH.

Location: 

Dar-es Salaam, Tanzania

Title: 

Program Manager, Cancer Collaboration Program, Muhimbili University of Health and Allied Sciences, Ocean Road Cancer Institute, and University of California San Francisco (MUHAS-ORCI-UCSF)

Foundation Role: 

Board member

Michael Mwachiro, MD

Location: 

Nairobi, Kenya

Title: 

Consultant General Surgeon and Interventional Endoscopist, Avenue HealthCare

Foundation Role: 

Board member

Ike Ogbuebile, MA, MiPD

Location: 

Washington DC area, USA

Title: 

Founder & CEO, Encase Consulting

Foundation Role: 

Board member

John Sims

Location: 

Boston, Massachusetts, USA

Title: 

President and CEO of AJS Consulting Company, LLC.

Foundation Role: 

Board member

Mark Topazian, MD

Location: 

Addis Ababa, Ethiopia

Title: 

Gastroenterologist

Foundation Role: 

Board member

David Fleischer, MD

Location: 

Washington DC, USA

Title: 

Emeritus Professor of Medicine Mayo Clinic College of Medicine

Foundation Role: 

Chairman, Board of Directors

Sanford (Sandy) Dawsey, MD

Location: 

Washington DC area, USA

Title: 

Retired Senior Investigator from the National Cancer Institute

Foundation Role: 

President, Board of Directors

Violet Kayamba, BScHB, MBChB, MMed, FCP(ECSA), Ph.D

Location: 

Lusaka, Zambia

Title: 

Senior Lecturer, University of Zambia School of Medicine

Foundation Role: 

Vice President, Board of Directors

Jim O'Hara

Location: 

Washington, DC area, USA

Title: 

CFO, PM Hotel Group

Foundation Role: 

Treasurer, Board of Directors

Dorene E. McCourt, MBA

Location: 

Boston, MA, USA

Title: 

Pharmaceutical marketing and sales executive (retired)

Foundation Role: 

Secretary, Board of Directors

Lilly Alfonso

Location: 

Lilongwe, Malawi

Title: 

CEO, Founder & Head Designer, Lilly Alfonso

Foundation Role: 

Board Member

Vivian Kobusingye Birchall, SM

Location: 

Massachusetts, USA

Title: 

Founder & CEO, Health Care Blind Spots Consulting

Foundation Role: 

Board Member

Geoffrey (Geoff) Buckle, MD, MPH

Location: 

San Francisco, California, USA

Title: 

Assistant Professor in the Division of Hematology/Oncology at the University of California, San Francisco (UCSF)

Foundation Role: 

Board member

AfrECC's board members are spread across 19 countries, contributing their global perspectives to our mission.

Sanford (Sandy) Dawsey, MD

Location: Washington DC area, US

Title: Retired Senior Investigator from the National Cancer Institute

Foundation Role: President, Board of Directors

Violet Kayamba, BScHB, MBChB, MMed, FCP (ECSA),

Location: Lusaka, Zambia

Title: Senior Lecturer, University of Zambia School of Medicine

Foundation Role: Vice President, Board of Directors

Dorene E. McCourt, MBA

Location: Boston, MA and Burlington, WI, US

Title: Pharmaceutical marketing and sales executive (retired)

Foundation Role: Secretary, Board of Directors

Robby Vanrijkel, MBA, MSc, BSc, BComm

Location: McLean, VA, US

Title: Industry Specialty Services (Nonprofit & Grantmakers Advisory) – Principal

Foundation Role: Treasurer, Board of Directors

Geoffrey Buckle, MD, MPH

Location: San Francisco, CA, US

Title: Assistant Professor in the Division ofHematology/Oncology at the University of California, San Francisco (UCSF)

Foundation Role: Board member

Chloe Cooney

Location: Washington DC, US 

Title: Director of U.S. Strategy for Gavi

Foundation Role: Board member; Leader of Strategic Planning Task Force

Beatrice Paul Mushi, MD, MPH

Location: Dar-es Salaam, Tanzania

Title: Program Manager, Cancer Collaboration Program, Muhimbili University of Health and Allied Sciences, Ocean Road Cancer Institute, and University of California San Francisco (MUHAS-ORCI-UCSF)

Foundation Role: Board member

Diana Menya, BSc, MBChB, MSc, PhD

Location: 

Eldoret, Kenya

Title: 

Epidemiologist, Moi University

Foundation Role: 

Board member

Gift Mulima, MD

Location: 

Lilongwe, Malawi

Title: 

General Surgeon, Kamuzu Central Hospital

Foundation Role: 

Board member

Jerome (Jerry) D. Waye, MD

Location: 

New York, US

Title: 

Emeritus Professor of Medicine, Mt Sinai, New York

Foundation Role: 

Board member; Leader of the Remote Endoscopic Teaching Task Force

Michael Mwachiro, MD

Location: 

Nairobi, Kenya

Title: 

Consultant General Surgeon and Interventional Endoscopist, Avenue Health Care

Foundation Role: 

Board member

Mark Topazian, MD

Location: 

Addis Ababa, Ethiopia

Title: 

Gastroenterologist, Saint Paul’s Hospital Millennial Medical Center

Foundation Role: 

Board member

Ogbuebile, MA, MiPD

Location: 

Washington DC, US

Title: 

Founder & CEO, Encase Consulting

Foundation Role: 

Board member